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The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motor

2026-06-06

Abstract excerpt

β-cardiac myosin is the primary motor protein in the human heart responsible for force generation by converting chemical energy from ATP hydrolysis to mechanical work. It binds actin, produces force through its powerstroke, and releases actin, and must complete this cycle several times a second within each heartbeat. Like other muscle myosins, cardiac myosin has a low duty ratio of ∼5%, the fraction of time in the...

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Literature Corpus work
cafbb00c-3c1f-508b-b8a6-e5043a30a656
DOI
10.64898/2026.06.02.729673
Open publication

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The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motorDOI 10.64898/2026.06.02.729673
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