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Implication of novel variants of <i>BMP2</i> in isolated congenital heart disease: Functional characterization by <i>in silico</i> and <i>invitro</i> approaches

2025-08-31

Abstract excerpt

Bone morphogenic protein2 (BMP2), a member of TGF-β super-family, known to play a wide range of roles during embryonic development, particularly in the formation of bone/skeleton, differentiation of neurons, skeletal muscle, and development of cardiac valve septa and outflow tract. BMP2 haploinsufficiency is reported to cause multiple congenital malformations including cardiac defects mainly endocardial cushion f...

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Literature Corpus work
e319b916-ae27-58d5-89f6-925cee280491
DOI
10.1101/2025.08.29.672127
Open publication

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Implication of novel variants of <i>BMP2</i> in isolated congenital heart disease: Functional characterization by <i>in silico</i> and <i>invitro</i> approachesDOI 10.1101/2025.08.29.672127
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