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Article

Common variations in BMP4 confer genetic susceptibility to sporadic congenital heart disease in a Han Chinese population.

Pediatric cardiology - 1 Dec 2014

Qian Bo, Mo Ran, Da Min, Peng Wei, Hu Yuanli, Mo Xuming

Abstract excerpt

Congenital heart disease (CHD) is the most common birth defect in humans. The genetic causes of sporadic CHD remain largely unknown. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor-β (TGF-β) family, is required for normal heart development. Loss of BMP4 gene expression in mice is associated with septal defects, defective endocardial cushion remodeling, and abnormal semilunar valve...

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Source

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Identifiers

PMID: 25022354
DOI: 10.1007/s00246-014-0951-1
PMCID: PMC4236636

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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