Back to search

Article

Deciphering the functional association of novel variants of <i>BMP7</i> in isolated congenital heart disease by integrating <i>in vitro</i> and <i>in silico</i> approaches

2025-12-25

Abstract excerpt

Bone morphogenetic protein7 (BMP7), an important member of the TGFβ superfamily, is known to be vital for embryonic growth and development. To decipher the role of BMP7 in congenital cardiac malformations, genetic screening of 285 CHD cases along with 400 healthy controls individuals was performed by Sanger sequencing method. Five missense variants were identified in 5 unrelated CHD probands with distinct phenotyp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f5f0edda-7586-56f6-997f-a5613efbf9ea
DOI
10.64898/2025.12.23.696272
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Deciphering the functional association of novel variants of <i>BMP7</i> in isolated congenital heart disease by integrating <i>in vitro</i> and <i>in silico</i> approachesDOI 10.64898/2025.12.23.696272
Implication of novel variants of <i>BMP2</i> in isolated congenital heart disease: Functional characterization by <i>in silico</i> and <i>invitro</i> approachesSemantic proximity
Functionally significant, novel variants of <i>BMP4</i> are associated with isolated congenital heart diseaseSemantic proximity
SMAD4 loss-of-function mutation predisposes to congenital heart disease.Semantic proximity
SMAD1 Loss‐of‐Function Variant Responsible for Congenital Heart DiseaseSemantic proximity
CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in miceSemantic proximity
Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population.Semantic proximity
Clinical and molecular effects of CHD7 in the heart.Semantic proximity
Smad7 Is Required for the Development and Function of the HeartSemantic proximity
Current perspectives on inhibitory SMAD7 in health and diseaseSemantic proximity
Inhibitory Smad7: Emerging Roles in Health and DiseaseSemantic proximity
Common variations in BMP4 confer genetic susceptibility to sporadic congenital heart disease in a Han Chinese population.Semantic proximity
Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes.Semantic proximity
Select a neighboring publication to make it the new centre.