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Article

Characterization of human bone morphogenetic protein gene variants for possible roles in congenital heart disease.

Molecular medicine reports - 1 Aug 2016

Li Fei-Feng, Deng Xia, Zhou Jing, Yan Peng, Zhao Er-Ying, Liu Shu-Lin

Abstract excerpt

Congenital heart disease (CHD) is a complex illness with high rates of morbidity and mortality. In embryonic development, the heart is the first formed organ, which is strictly controlled by gene regulatory networks, including transcription factors, signaling pathways, epigenetic factors and microRNAs. Bone morphogenetic protein (BMP)-2 and -4 are essential in cardiogenesis as they can induce the expression of...

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Identifiers

PMID: 27357418
DOI: 10.3892/mmr.2016.5428
PMCID: PMC4940093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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