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Article

Functional mutant GATA4 identification and potential application in preimplantation diagnosis of congenital heart diseases.

Gene - 30 Jan 2018

Yu You, Lei Wei, Yang Junjie, Wei Yan-Chang, Zhao Zhen-Ling, Zhao Zhen-Ao, Hu Shijun

Abstract excerpt

Congenital heart diseases (CHDs) affect nearly 1% of all neonates and show an increasing tendency. The complex inheritance patterns and multifactorial etiologies make these defects difficult to be identified before complete manifestation. Genetic screening has identified hundreds of specific mutant sites for CHDs based on cardiac transcriptional factors. GATA4 is a master regulator required for ventral...

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Source

Identifiers

PMID: 29111206
DOI: 10.1016/j.gene.2017.10.078

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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