Article

Association of IRX4 synonymous variants with congenital heart disease: Leveraging in-silico approaches to predict the functional impact

2025-08-08

Abstract excerpt

<title>Abstract</title> <p> Synonymous variants are often overlooked during genetic screening, however current reports forecasted their significant biological impact and inevitably considered pathogenic. These silent changes in genome significantly affect the mRNA structure and stability and hence, alter the protein expression and function. <italic>IRX4</italic> is an essential transcription factor for cardiog...

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Literature Corpus work: 44280d08-cb14-5820-b559-e70191125841
DOI: 10.21203/rs.3.rs-7192653/v1

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