Article

Polygenic Risk for Substance-Related Traits Predicts Substance Use Onset and Progression: Sex and Population Group Differences

2022-09-30

Abstract excerpt

<h4>Background</h4> Charting the clinical course of substance use disorders (SUDs) to identify etiologic contributors to milestone onset and progression could inform intervention efforts. <h4>Methods</h4> We calculated polygenic risk scores (PRS) in 5,692 European-ancestry individuals (EUR) (56.2% male) and 4,918 African-ancestry (AFR) individuals (54.9% male) using genome-wide association studies (GWAS) of alcoho...

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Literature Corpus work: 205730c2-6bdf-56ec-ba1d-4a36090e21bb
DOI: 10.1101/2022.09.29.22280477

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