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Article

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2024

Hartwell Emily E, Jinwala Zeal, Milone Jackson, Ramirez Sarah, Gelernter Joel, Kranzler Henry R, Kember Rachel L

Abstract excerpt

Co-occurring psychiatric, medical, and substance use disorders (SUDs) are common, but the complex pathways leading to such comorbidities are poorly understood. A greater understanding of genetic influences on this phenomenon could inform precision medicine efforts. We used the Yale-Penn dataset, a cross-sectional sample enriched for individuals with SUDs, to examine pleiotropic effects of genetic liability for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39043921
DOI: 10.1038/s41386-024-01922-2
PMCID: PMC11480112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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