Article

Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer Metastasis

2026-05-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Antibody-mediated blockade of innate receptor–MHC-I interactions represents a promising strategy to enhance anti-tumor immunity, particularly against metastatic cancers resistant to conventional checkpoint inhibitors. In this study, we investigated the effects of the pan anti-MHC-I monoclonal antibody M1/42, which targets MHC-I interactions with Ly49, selectively expressed o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2fe051d-7776-5dce-b5b2-319a0fcd19c4
DOI: 10.64898/2026.05.07.722994

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer MetastasisDOI 10.64898/2026.05.07.722994Read

p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancerSemantic proximity Read

p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancerSemantic proximity Read

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read

Macrophage Antigen Presentation Is Unleashed by Pan-RAS Inhibition to Promote Antitumor ImmunitySemantic proximity Read

Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine of IFNα and is enhanced by CD47 blockadeSemantic proximity Read

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read

B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanomaSemantic proximity Read

Tregs constrain CD8 <sup>+</sup> T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapySemantic proximity Read

Caerin 1.1 and 1.9 peptides halt B16 melanoma metastatic tumours via expanding cDC1 and reprogramming tumour macrophagesSemantic proximity Read

An immune-stimulating antibody conjugate spatiotemporally targeting CD47 and TLR9 elicits macrophage-dependent tumor clearance and durable anti-cancer adaptive immunitySemantic proximity Read

Caerin 1.1 and 1.9 peptides halt B16 melanoma metastatic tumours via expanding cDC1 and reprogramming tumour macrophagesSemantic proximity Read

Novel Immune Drug Combination Induces Tumour Microenvironment Remodelling and Reduces the Dosage of Anti-PD-1 AntibodySemantic proximity Read