Article

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control

2021-10-27

Abstract excerpt

<h4>Background: </h4> MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to the activating receptor NKG2D on cytotoxic lymphocytes. MICA and MICB are highly polymorphic molecules with prevalent expression on several types of solid tumors and limited expression in normal/healthy tissues, making them attractive targets for therapeutic intervention. <h4>Methods: </h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: baf91aaf-bafa-539d-a964-8a9f4862b0d6
DOI: 10.12688/openreseurope.13314.2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlDOI 10.12688/openreseurope.13314.2Read

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read

Leveraging NKG2D Ligands in Immuno-OncologySemantic proximity Read

MHC class I chain-related A: Polymorphism, regulation and therapeutic value in cancer.Semantic proximity Read

Targets of Protective Tumor ImmunitySemantic proximity Read

NKG2D and MICA/B shedding: a ‘tag game’ between NK cells and malignant cellsSemantic proximity Read

Membrane-bound versus soluble major histocompatibility complex Class I-related chain A and major histocompatibility complex Class I-related chain B differential expression: Mechanisms of tumor eradication versus evasion and current drug development strategies.Semantic proximity Read

Production and characterization of monoclonal antibodies against major histocompatibility complex class I chain-related gene A.Semantic proximity Read

A MICA/B GAALIE-mutant antibody elicits potent natural killer cell-driven immunity in solid and hematologic malignancy models.Semantic proximity Read

Obstructing Shedding of the Immunostimulatory MHC Class I Chain–Related Gene B Prevents Tumor FormationSemantic proximity Read

Muc1 ImmunotherapySemantic proximity Read

Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer MetastasisSemantic proximity Read

An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding.Semantic proximity Read