Article

Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine of IFNα and is enhanced by CD47 blockade

2023-12-13

Abstract excerpt

<title>Abstract</title> Background Immunotherapy has greatly changed the landscape of cancer therapy; however, only a subset of patients responds to immune checkpoint blockade or to CAR-T based therapy. Previously, we demonstrated that natural host-defence peptide caerin1.1/caerin1.9 (F1/F3) increases the efficacy of anti-PD-1 and therapeutic vaccine, in a HPV16 + TC-1 tumour model, but the anti-tumor mechani...

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Literature Corpus work: fa8e1778-1b2e-5fd2-94a4-c4ff26b34d3a
DOI: 10.21203/rs.3.rs-3697564/v1

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