Article

Macrophage Antigen Presentation Is Unleashed by Pan-RAS Inhibition to Promote Antitumor Immunity

2026-02-02

Abstract excerpt

Pan-RAS inhibitors have emerged as potent targeted therapies designed to suppress oncogenic signaling in RAS-mutant tumors. However, whether these inhibitors possess therapeutic utility beyond tumors with intrinsic RAS dependency remains unclear. Here we show that the clinical-stage pan-RAS(ON) inhibitor RMC-6236 (Daraxonrasib) induces robust regression of NRAS–wild-type B16 tumors in immunocompetent mice, a respo...

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Literature Corpus work: fc114bf8-7d44-51b9-9f2d-678d456739b8
DOI: 10.64898/2026.01.30.702886

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