Article

Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect splicing

2020-08-31

Abstract excerpt

Eukaryotic messenger RNAs are extensively decorated with modified nucleotides and the resulting epitranscriptome plays important regulatory roles in cells 1 . Pseudouridine (Ψ) is a modified nucleotide that is prevalent in human mRNAs and can be dynamically regulated 2–5 . However, it is unclear when in their life cycle RNAs become pseudouridylated and what the endogenous functions of mRNA pseudouridylation are....

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Literature Corpus work: 0975e644-769e-5c8e-b2e9-6e11e21cb89a
DOI: 10.1101/2020.08.29.273565

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