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Article

mRNA structure determines modification by pseudouridine synthase 1.

Nature chemical biology - 1 Oct 2019

Carlile Thomas M, Martinez Nicole M, Schaening Cassandra, Su Amanda, Bell Tristan A, Zinshteyn Boris, Gilbert Wendy V

Abstract excerpt

Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions that affect gene expression. Messenger RNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms responsible for selective, regulated pseudouridylation of specific sequences within mRNAs were unknown. Here, we have revealed mRNA targets for five...

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Identifiers

PMID: 31477916
DOI: 10.1038/s41589-019-0353-z
PMCID: PMC6764900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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