Article

Enhancing Mendelian Randomization Causal Inference through Pleiotropic Clustering in the Presence of Correlated Horizontal Pleiotropy

2024-05-09

Abstract excerpt

<title>Abstract</title> <p>Correlated horizontal pleiotropy poses a formidable challenge in Mendelian randomization (MR). Existing methods, relying on sparse pleiotropic variants or zero modal pleiotropy assumption (ZEMPA), may face issues, especially in trait pairs with a high proportion of correlated horizontal pleiotropic variants. We propose an innovative Pleiotropic Clustering model for MR analysis (PCMR) to...

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Literature Corpus work: afac392d-49f6-57c2-9ef7-a6fc92e111c1
DOI: 10.21203/rs.3.rs-4116880/v1

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