Article

Critical role for the TGF-β1/mTORC1 signalling axis in defining the transcriptional identity of <i>CTHRC1</i> + pathologic fibroblasts

2024-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Fibrosis, defined as the abnormal deposition of extracellular matrix (ECM), represents the concluding pathological outcome in a number of inflammatory, immune-mediated and metabolic diseases. Recent single cell RNA-sequencing studies have highlighted the diversity and functional heterogeneity of fibroblast populations in multiple fibrotic conditions. These include a novel pathogenic population o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be449af3-ed05-51ae-be6f-ca53346cb718
DOI: 10.1101/2024.10.12.617979

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Critical role for the TGF-β1/mTORC1 signalling axis in defining the transcriptional identity of <i>CTHRC1</i> + pathologic fibroblastsDOI 10.1101/2024.10.12.617979Read

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesisSemantic proximity Read

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.Semantic proximity Read

Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosisSemantic proximity Read

Bulk RNA-Sequencing of small airway cell cultures from IPF and post-COVID lung fibrosis patients illustrates disease signatures and differential responses to TGF- <i>β</i> 1 treatmentSemantic proximity Read

Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulationSemantic proximity Read

PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in miceSemantic proximity Read

Mapping fibroblast plasticity across non-cancer lung diseases at single-cell resolutionSemantic proximity Read

Single-Cell RNA-Sequencing Identifies Bone Marrow-Derived Progenitor Cells as a Main Source of Extracellular Matrix-Producing Cells Across Multiple Organ-Based Fibrotic DiseasesSemantic proximity Read

Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosisSemantic proximity Read

RNA-sequencing comparison of pneumonectomy and bleomycin reveals anti-fibrotic mechanisms of lung fibroblastsSemantic proximity Read

Transcriptional Profiling of Rapamycin-Treated Fibroblasts From Hypertrophic and Keloid ScarsSemantic proximity Read