Article

Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis

2018-09-26

Abstract excerpt

Idiopathic pulmonary fibrosis is a fatal, incurable lung disease in which the intricate alveolar network of the human lung is progressively replaced by fibrotic scars, eventually leading to respiratory failure. Myofibroblasts are the effector cells that lead to abnormal deposition of extracellular matrix proteins and therefore mediate fibrotic disease not only in the lung but also in other organs. Emerging literat...

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Literature Corpus work: de73c939-725d-5be1-9261-32b52a7354be
DOI: 10.1101/401265

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