TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation

Abstract excerpt

<h4>ABSTRACT</h4> Alveolar macrophages (AMs) are key mediators of lung function and are potential targets for therapies during respiratory infections. TGFβ is an important regulator of AM differentiation and maintenance, but how TGFβ directly modulates the innate immune responses of AMs remains unclear. This shortcoming prevents effective targeting of AMs to improve lung function in health and disease. Here we le...

Topics

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• Animals, Newborn
• Disease Models, Animal
• Liver
• Lung
• Macrophages, Alveolar
• Mice, Inbred C57BL
• Neonatal Respiratory Health Research
• TGF-β signaling in diseases

Identifiers and source

Literature Corpus work

bb16e66f-de57-560b-a5d1-192cd4594b0f

DOI

10.1101/2024.09.04.611226