Article

HSF1 controls transcriptional programs that establish thalamostriatal shaft synaptic architecture and preserve cognitive flexibility

2026-08-07

Abstract excerpt

Cognitive flexibility (CF) declines during aging and is further impaired in neurodegenerative diseases such as Huntington’s disease (HD), yet the molecular mechanisms underlying these deficits remain poorly understood. Thalamostriatal (T-S) synapses are critical for CF, and we previously identified Heat Shock Factor 1 (HSF1) as a regulator of T-S density in HD. However, how HSF1 regulates T-S synapses and whether...

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Literature Corpus work: e2a2142c-9a75-56f0-962b-1f1eb2478617
DOI: 10.64898/2026.08.03.742053

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