Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.

Cell reports - 5 Dec 2017

Hachigian Lea J, Carmona Vitor, Fenster Robert J, Kulicke Ruth, Heilbut Adrian, Sittler Annie, Pereira de Almeida Luís, Mesirov Jill P, Gao Fan, Kolaczyk Eric D, Heiman Myriam

Abstract excerpt

Alteration of corticostriatal glutamatergic function is an early pathophysiological change associated with Huntington's disease (HD). The factors that regulate the maintenance of corticostriatal glutamatergic synapses post-developmentally are not well understood. Recently, the striatum-enriched transcription factor Foxp2 was implicated in the development of these synapses. Here, we show that, in mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Fluorescent Antibody Technique, Indirect

Share to Forkhead Transcription Factors

Share to Gene Expression Regulation

Share to Huntington Disease

Share to Repressor Proteins

Source

Identifiers

PMID: 29212017
DOI: 10.1016/j.celrep.2017.11.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.PMID 29212017Read ↗

FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatementSemantic proximity Read ↗

FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement.Semantic proximity Read ↗

Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.Semantic proximity Read ↗

Mice carrying a humanized <i>Foxp2</i> knock-in allele show region-specific shifts of striatal Foxp2 expression levelsSemantic proximity Read ↗

Postnatal Foxp2 regulates early psychiatric-like phenotypes and associated molecular alterations in the R6/1 transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Single-cell analysis of Foxp1-driven mechanisms essential for striatal developmentSemantic proximity Read ↗

Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s DiseaseSemantic proximity Read ↗

What can mice tell us about Foxp2 function?Semantic proximity Read ↗

The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders.Semantic proximity Read ↗

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.Semantic proximity Read ↗

FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesisSemantic proximity Read ↗

Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.