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Article

Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.

Journal of Huntington's disease - 1 Jan 2012

Riva Laura, Koeva Martina, Yildirim Ferah, Pirhaji Leila, Dinesh Deepika, Mazor Tali, Duennwald Martin L, Fraenkel Ernest

Abstract excerpt

In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutant Htt in disease models, suggesting that the heat shock response is impaired in the disease. To understand the basis for this...

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Source

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Identifiers

PMID: 23293686
PMCID: PMC3537492

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.PMID 23293686Read ↗

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.Semantic proximity Read ↗

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregationSemantic proximity Read ↗

Chromatin conformation remains stable upon extensive transcriptional changes driven by heat shockSemantic proximity Read ↗

Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic DensitySemantic proximity Read ↗

Heat Shock Factor 1-Regulated miRNAs Can Target Huntingtin and Suppress Aggregates of Mutant Huntingtin.Semantic proximity Read ↗

HSF2 protects against proteotoxicity by maintaining cell-cell adhesionSemantic proximity Read ↗

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse modelsSemantic proximity Read ↗

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