Article

SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington’s disease progression

2021-11-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor dysfunction and loss of medium spiny neurons (MSNs) in dorsal striatum. Brain-derived neurotrophic factor (BDNF) sustains functionality and integrity of MSNs, and thus reduced BDNF signaling is integral to the disease. Mutations in BDNF receptor SorCS2 were recently identified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90d9ddc2-cce2-5560-9af5-a9fc4fb02b6e
DOI: 10.1101/2021.11.03.466767

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington’s disease progressionDOI 10.1101/2021.11.03.466767Read

SorCS2 Dynamically Interacts with TrkB and GluN2B to Control Neurotransmission and Huntington’s Disease ProgressionSemantic proximity Read

Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip modelSemantic proximity Read

A Study of the SORL1 Gene in the Pathogenesis of Late-onset Alzheimer’s Disease by Affecting the Expression of BDNFSemantic proximity Read

BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington’s DiseaseSemantic proximity Read

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult miceSemantic proximity Read

The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Semantic proximity Read

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington’s DiseaseSemantic proximity Read

Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.Semantic proximity Read

Impact of NRSN2 Deficiency on Memory: Disruption of Excitatory Synaptic Plasticity Linked to Reduced Expression of NMDA Receptor Subunits and impaired LTP in the hippocampusSemantic proximity Read

Multi-Scale Molecular Deconstruction of the Serotonin Neuron System.Semantic proximity Read

Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.Semantic proximity Read

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.Semantic proximity Read