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Article

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.

The Journal of clinical investigation - 1 Aug 2011

Labbadia John, Cunliffe Helen, Weiss Andreas, Katsyuba Elena, Sathasivam Kirupa, Seredenina Tamara, Woodman Ben, Moussaoui Saliha, Frentzel Stefan, Luthi-Carter Ruth, Paganetti Paolo, Bates Gillian P

Abstract excerpt

Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that activation of the heat shock response (HSR) via the transcription factor heat shock factor 1 (HSF1) may be of therapeutic benefit. However, the effect of disease progression on the HSR and the therapeutic potential of this pathway are currently unknown. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21785217
DOI: 10.1172/JCI57413
PMCID: PMC3148745

Genes

HSF1

Provenance

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Related research

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Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.PMID 21785217Read ↗

Overexpression of heat shock protein 70 in R6/2 Huntington’s disease mice has only modest effects on disease progressionSemantic proximity Read ↗

Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.Semantic proximity Read ↗

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse modelsSemantic proximity Read ↗

Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.Semantic proximity Read ↗

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models.Semantic proximity Read ↗

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregationSemantic proximity Read ↗

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specificSemantic proximity Read ↗

Heat Shock Factor 1-Regulated miRNAs Can Target Huntingtin and Suppress Aggregates of Mutant Huntingtin.Semantic proximity Read ↗

Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic DensitySemantic proximity Read ↗

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Amplifying the heat shock response ameliorates ALS and FTD pathology in mouse and human models.Semantic proximity Read ↗

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