Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington’s disease

5 May 2021

Abstract excerpt

Significance Although the genetic basis of HD is known, the molecular mechanisms underlying neuronal dysfunction remain unclear. Combining electrophysiological and transcriptional analyses of single neurons (Patch-sequencing [Patch-seq]), this study connects transcriptional dysregulation and synaptic transmission deficits, two key disease features, in HD. We identify a number of genes whose expression changes are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33952696
DOI: 10.1073/pnas.2020293118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington’s diseasePMID 33952696Read ↗

Transcriptomically-measured gene expression predicts physiological variation across single neurons in humans and miceSemantic proximity Read ↗

Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neuronsSemantic proximity Read ↗

Autism spectrum disorder risk genes have convergent effects on transcription and neuronal firing patterns in primary neurons.Semantic proximity Read ↗

Integrated multiomic profiling of <i>SCN2A</i> loss-of-function reveals widespread molecular remodeling in patient hiPSC-derived neuronsSemantic proximity Read ↗

ZCCHC17 knockdown phenocopies Alzheimer's disease-related loss of synaptic proteins and hyperexcitability.Semantic proximity Read ↗

Scn4b Modulates Huntington’s Disease Phenotype Severity in vivoSemantic proximity Read ↗

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.Semantic proximity Read ↗

SynTEF1 restores the functional disease phenotype of SCA27B in an hiPSC-derived neuronal disease modelSemantic proximity Read ↗

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD- associated Transcriptomic Networks and PathologySemantic proximity Read ↗

CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington’s Disease, Including Genetic Modifiers of Neuronal Development and MorphologySemantic proximity Read ↗

Multimodal profiling of human sensory neurons links electrical properties to transcriptional identitySemantic proximity Read ↗

RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.