Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synaptopathy, circuitopathy and the computational biology of Huntington's disease.

BMC biology - 27 Jun 2018

Hannan Anthony J

Abstract excerpt

Huntington's disease (HD) is one of the most common tandem repeat disorders and presents as a unique trilogy of cognitive, psychiatric and motor symptoms. One of the major mysteries of HD is why it selectively affects specific neuronal populations. A new article in BMC Biology provides a piece in the puzzle of pathogenesis. By demonstrating the delicate relationship between cortical and striatal neurons, it...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Computational Biology
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 29945620
DOI: 10.1186/s12915-018-0539-y
PMCID: PMC6020369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synaptopathy, circuitopathy and the computational biology of Huntington's disease.PMID 29945620Read ↗

Huntington's disease: a synaptopathy?Semantic proximity Read ↗

Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathwaySemantic proximity Read ↗

Synaptic Dysfunction in Huntington’s Disease: Lessons from Genetic Animal ModelsSemantic proximity Read ↗

Huntington’s disease and striatal signalingSemantic proximity Read ↗

Huntington disease: a single-gene degenerative disorder of the striatumSemantic proximity Read ↗

[Huntington's disease: cellular and molecular basis of pathology].Semantic proximity Read ↗

Genetic Mouse Models of Huntington’s Disease: Focus on Electrophysiological MechanismsSemantic proximity Read ↗

Synaptic dysfunction in Huntington's disease: a new perspective.Semantic proximity Read ↗

Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and SurvivalSemantic proximity Read ↗

Temporal single-cell atlas of full-length Huntington’s disease mouse model defines stage-specific signatures of corticostriatal dysfunctionSemantic proximity Read ↗

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.Semantic proximity Read ↗

Huntingtin and the SynapseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.