Article

Genome-wide CRISPR screen reveals genetic modifiers of Ca <sup>2+</sup> -mediated cell death

2023-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Ca 2+ is a fundamental determinant of survival in living cells. Excessive intracellular Ca 2+ causes cellular toxicity and death but the genetic pathways contributing to Ca 2+ induced cell death are incompletely understood. Here, we performed genome-wide CRISPR knock-out screening in human cells challenged with the Ca 2+ ionophore ionomycin and identified genes and pathways essential for cel...

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Literature Corpus work: e2a089c2-9f9f-5751-a4e7-ae8abcf4381d
DOI: 10.1101/2023.01.13.523980

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Genome-wide CRISPR screen reveals genetic modifiers of Ca <sup>2+</sup> -mediated cell deathDOI 10.1101/2023.01.13.523980Read

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