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A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets

2026-04-20

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(1) <h4>Aims and hypothesis</h4> Loss-of-function mutations in SLC30A8 , encoding the zinc ion (Zn 2+ ) transporter ZnT8 in pancreatic beta cells, lower type 2 diabetes risk dose-dependently, but the underlying mechanisms remain unclear. Here, we combine proteomic, transcriptomic and functional approaches in human stem cell-derived islet-like clusters bearing common alleles or the inactivating variant R138X. We...

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Literature Corpus work: 2ed78508-7ddd-5652-a0be-0471d71822fe
DOI: 10.64898/2026.04.17.26351108

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A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived isletsDOI 10.64898/2026.04.17.26351108Read

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A loss of function variant in <i>SLC30A8/ZnT8</i> drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets

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