Article
When calcium goes wrong: genetic alterations of a ubiquitous signaling route.
Nature genetics - 1 Jun 2003
Rizzuto Rosario, Pozzan Tullio
Abstract excerpt
In all eukaryotic cells, the cytosolic concentration of calcium ions ([Ca2+]c) is tightly controlled by complex interactions among transporters, pumps, channels and binding proteins. Finely tuned changes in [Ca2+]c modulate a variety of intracellular functions, and disruption of Ca2+ handling leads to cell death. Here we review the human genetic diseases associated with perturbations in the Ca2+ signaling...
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