Article

Stimulus-Secretion Coupling Mechanisms of Glucose-Induced Insulin Secretion: Biochemical Discrepancies Among the Canonical, ADP-Privation, and GABA-Shunt Models

2025-02-27

Abstract excerpt

Analysis of precedent and new data should allow now and then to suggest modifications for a future integral view of the stimulus-secretion coupling of glucose-induced insulin secretion. The main purpose of this review is to supply only biochemical considerations about some of the metabolic pathways implicated in the process of insulin secretion. It is emphasized that glucose β-cells’ threshold to activate secretio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e29859dd-28ac-5262-bad3-3532ca840d68
DOI: 10.20944/preprints202502.2235.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stimulus-Secretion Coupling Mechanisms of Glucose-Induced Insulin Secretion: Biochemical Discrepancies Among the Canonical, ADP-Privation, and GABA-Shunt ModelsDOI 10.20944/preprints202502.2235.v1Read

A plasma membrane-associated glycolytic metabolon is functionally coupled to K <sub>ATP</sub> channels in pancreatic α and β cells from humans and miceSemantic proximity Read

Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit.Semantic proximity Read

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and SignalingSemantic proximity Read

Glutaminolysis and insulin secretion: from bedside to bench and back.Semantic proximity Read

Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMPSemantic proximity Read

Excessive iron accumulation mediated oxidative stress and β-cell dysfunction via perturbations of insulin secretion in MIN6 cellsSemantic proximity Read

Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism.Semantic proximity Read

Assessing the Rate-Dependence of the First Phase of Glucose-Stimulated Insulin Secretion: Dynamic Perifusion Studies with Isolated Human Pancreatic IsletsSemantic proximity Read

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.Semantic proximity Read

Pathophysiology of impaired pulsatile insulin release.Semantic proximity Read

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.Semantic proximity Read