Article
Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.
The Journal of biological chemistry - 9 Jan 2009
Carobbio Stefania, Frigerio Francesca, Rubi Blanca, Vetterli Laurène, Bloksgaard Maria, Gjinovci Asllan, Pournourmohammadi Shirin, Herrera Pedro L, Reith Walter, Mandrup Susanne, Maechler Pierre
Abstract excerpt
Insulin exocytosis is regulated in pancreatic ss-cells by a cascade of intracellular signals translating glucose levels into corresponding secretory responses. The mitochondrial enzyme glutamate dehydrogenase (GDH) is regarded as a major player in this process, although its abrogation has not been tested yet in animal models. Here, we generated transgenic mice, named betaGlud1(-/-), with ss-cell-specific GDH...
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