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Article

Pathophysiology of impaired pulsatile insulin release.

Diabetes/metabolism research and reviews - 1 Jan 2000

Bergsten P

Abstract excerpt

Plasma insulin displays 5-10 min oscillations. In Type 2 diabetes the regularity of the oscillations disappears, which may lead to insulin receptor down-regulation and glucose intolerance and explain why pulsatile delivery of the hormone has a greater hypoglycemic effect than continuous delivery. The rhythm is intrinsic to the islet. Variations in metabolism, cytoplasmic Ca(2+) concentration ([Ca(2+)](i)), other...

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Identifiers

PMID: 10867718
DOI: 10.1002/1520-7560(200005/06)16:3<179::aid-dmrr115>3.0.co;2-c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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