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Article

Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism.

Acta biochimica et biophysica Sinica - 1 Jan 2013

Zhang Tingting, Li Changhong

Abstract excerpt

The role of amino acids in the regulation of insulin secretion in pancreatic beta-cells is highlighted in three forms of congenital hyperinsulinism (HI), namely gain-of-function mutations of glutamate dehydrogenase (GDH), loss-of-function mutations of ATP-dependent potassium channels, and a deficiency of short-chain 3-hydroxyacyl-CoA dehydrogenase. Studies on disease mouse models of HI suggest that amino acid...

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Identifiers

PMID: 23212075
DOI: 10.1093/abbs/gms107
PMCID: PMC3527006

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