Article

A plasma membrane-associated glycolytic metabolon is functionally coupled to K <sub>ATP</sub> channels in pancreatic α and β cells from humans and mice

2022-10-06

Abstract excerpt

<h4>Summary</h4> The ATP-sensitive K + channel (K ATP ) is a key regulator of hormone secretion from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in pancreatic β cells and the lesser-studied α cells, from both humans and mice, we demonstrate that a glycolytic metabolon locally controls K ATP channels on the plasma membrane. The two ATP-consuming enzymes of upper glycol...

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Literature Corpus work: a83aafbc-aefd-5506-9b1a-69a7ec2a0a08
DOI: 10.1101/2022.10.06.511200

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