Article

Genetic landscape of an <i>in vivo</i> protein interactome

2023-12-15

Abstract excerpt

<h4>SUMMARY</h4> Protein-protein interaction (PPI) networks accurately map environmental perturbations to their molecular consequences in cells, but effects of genome-wide genetic variation on PPIs remain unknown. We hypothesized that PPI networks integrate genetic and environmental effects, potentially defining biochemical mechanisms underlying complex polygenic traits. Here, we measured 61 PPIs in inbred strain...

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Literature Corpus work: e292e2a8-c4b2-5daa-9f53-d8245d4073c8
DOI: 10.1101/2023.12.14.571726

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