Article

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma

2019-01-01

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is characterised by frequent inactivation of the VHL tumour suppressor gene and consequent accumulation of HIF2A that drives tumourigenesis. The current clinically-approved therapies for ccRCC are those targeting the angiogenesis and mTOR signalling pathways, however, the overall patients' objective response rates are still low, and patients rapidly develop resistance toward...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2926d73-eb06-599f-a3c1-27ef390fbd62
DOI: 10.17863/cam.41576

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinomaDOI 10.17863/cam.41576Read

VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.Semantic proximity Read

The Multi-Omics Analyses of ACSL1 Reveal Its Translational Significance as a Tumor Microenvironmental and Prognostic Biomarker in Clear Cell Renal Cell CarcinomaSemantic proximity Read

The multi-omics analyses of acsl1 reveal its translational significance as a tumor microenvironmental and prognostic biomarker in clear cell renal cell carcinomaSemantic proximity Read

Chromatin accessibility shapes tumor architecture and microenvironment in clear cell renal cell carcinomaSemantic proximity Read

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in miceSemantic proximity Read

VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling.Semantic proximity Read

Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinomaSemantic proximity Read

Comprehensive molecular characterization of clear cell renal cell carcinoma.Semantic proximity Read

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinomaSemantic proximity Read

Integrated Multi-Omics Analysis Reveals Folate Metabolism Related Genes as Prognostic Markers and Therapeutic Targets in Clear Cell Renal Cell CarcinomaSemantic proximity Read

Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinomaSemantic proximity Read

Lipid in Renal Carcinoma: Queen Bee to Target?Semantic proximity Read