VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

doi:10.1158/2159-8290.CD-17-0375

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Article

VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

Cancer discovery - 1 Nov 2017

Yao Xiaosai, Tan Jing, Lim Kevin Junliang, Koh Joanna, Ooi Wen Fong, Li Zhimei, Huang Dachuan, Xing Manjie, Chan Yang Sun, Qu James Zhengzhong, Tay Su Ting, Wijaya Giovani, Lam Yue Ning, Hong Jing Han, Lee-Lim Ai Ping, Guan Peiyong, Ng Michelle Shu Wen, He Cassandra Zhengxuan, Lin Joyce Suling, Nandi Tannistha, Qamra Aditi, Xu Chang, Myint Swe Swe, Davies James O J, Goh Jian Yuan, Loh Gary, Tan Bryan C, Rozen Steven G, Yu Qiang, Tan Iain Bee Huat, Cheng Christopher Wai Sam, Li Shang, Chang Kenneth Tou En, Tan Puay Hoon, Silver David Lawrence, Lezhava Alexander, Steger Gertrud, Hughes Jim R, Teh Bin Tean, Tan Patrick

Abstract excerpt

Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively characterized, frequently involving inactivation of the von Hippel-Lindau (VHL) tumor suppressor. Roles for noncoding cis-regulatory aberrations in ccRCC tumorigenesis, however, remain unclear. Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in...

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PMID: 28893800
DOI: 10.1158/2159-8290.CD-17-0375

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