Article

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

2023-01-27

Abstract excerpt

Chimeric antigen receptor (CAR) engineered T cells often fail to enact effector functions after infusion into patients. Understanding the biological pathways that lead CAR T cells to failure is of critical importance in the design of more effective therapies. We developed and validated an in vitro model that drives T cell dysfunction through chronic CAR activation and interrogated how CAR costimulatory domains co...

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Literature Corpus work: e291b4ae-fe05-5484-9d4f-c408e3f8e46e
DOI: 10.1101/2023.01.26.525725

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