Article

FOXO1 is a master regulator of CAR T memory programming

2023-11-07

Abstract excerpt

<title>Abstract</title> <p>Poor CAR T persistence limits CAR T cell therapies for B cell malignancies and solid tumors<sup>1,2</sup>. The expression of memory-associated genes such as TCF7 (protein name TCF1) is linked to response and long-term persistence in patients<sup>3-7</sup>, thereby implicating memory programs in therapeutic efficacy. Here, we demonstrate that the pioneer transcription factor, FOXO1, is r...

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Literature Corpus work: 3e302e1e-97fa-5eb8-b203-454f0fa12490
DOI: 10.21203/rs.3.rs-2802998/v1

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