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Article

Differential susceptibility and role for senescence in CART cells based on costimulatory domains

10 Jun 2025

Abstract excerpt

Despite the success of chimeric antigen receptor T (CART) cell therapy in hematological malignancies, durable remissions remain low. Here, we report CART senescence as a potential resistance mechanism in 41BB-costimulated CART cell therapy. To mimic cancer relapse, we utilized an in vitro model with repeated CART cell activation cycles followed by rest periods. Using CD19-targeted CART cells with costimulation...

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PMID: 40495168
DOI: 10.1186/s12943-025-02371-1

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