Article

Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease

2026-06-09

Abstract excerpt

<h4>Background</h4> Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst expansion, fibrosis and inflammation, leading to kidney failure. Myofibroblasts (MFs) often accumulate around cysts and promote fibrosis and cyst growth, but the cellular mechanisms enabling their pro-cystogenic activity remain unclear. Here we examined the role of autophagy within MFs, on their paracrine...

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Literature Corpus work: e276ea29-9377-5fc5-b232-af3ec244db0c
DOI: 10.64898/2026.06.05.730503

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