Article

Vascular transcriptional and metabolic changes precede progressive intra-renal microvascular rarefaction in autosomal dominant polycystic kidney disease

2025-07-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The mechanisms contributing to progressive kidney damage in autosomal dominant polycystic kidney disease (ADPKD) remain unclear. Renal microvascular (MV) rarefaction plays an important role in kidney disease, but its natural history, underlying mechanisms, and contributions to renal disease progression in ADPKD remain unknown. We hypothesized that intrarenal MV rarefaction i...

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Literature Corpus work: 7bff8838-2e30-5fe0-80cb-1a82ecc261ae
DOI: 10.1101/2025.06.30.662386

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