Article
Autophagy induction promotes renal cyst growth in polycystic kidney disease.
EBioMedicine - 1 Oct 2020
Lee Eun Ji, Ko Je Yeong, Oh Sumin, Jun Jaehee, Mun Hyowon, Lim Chae Ji, Seo Seungwoon, Ko Hyuk Wan, Kim Hyunho, Oh Yun Kyu, Ahn Curie, Kang Minyong, Kim Min Jung, Yoo Kyung Hyun, Oh Goo Taeg, Park Jong Hoon
Abstract excerpt
BACKGROUND: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been recently suggested as a potential therapeutic target in PKD, and mammalian target of rapamycin (mTOR) is a key negative regulator of autophagy. However, the effect of autophagy regulation on cystogenesis has not been elucidated in PKD mice. METHODS: Clinical validation was performed using...
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