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Article

Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in Pkd1-Deficient Mice.

Journal of the American Society of Nephrology : JASN - 1 Sept 2018

Yang Yang, Chen Meihan, Zhou Jie, Lv Jiayi, Song Shuwei, Fu LiLi, Chen Jiejian, Yang Ming, Mei Changlin

Abstract excerpt

BACKGROUND: Autosomal-dominant polycystic kidney disease (ADPKD) is the leading inherited renal disease worldwide. The proproliferative function of macrophages is associated with late-stage cyst enlargement in mice with PKD; however, the way in which macrophages act on cyst-lining epithelial cells (CLECs) has not been well elucidated. METHODS: We generated a rapid-onset PKD mouse model by inactivating Pkd1 on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30042193
DOI: 10.1681/ASN.2018010074
PMCID: PMC6115670

Genes

ARG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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