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H <sub>2</sub> O <sub>2</sub> -induced astrocytic collagen triggers neuronal death via fucosylation-dependent glial barrier formation upon ischemic stroke

2025-05-06

Abstract excerpt

<h4>Summary</h4> The cascade of molecular and cellular events leading to neuronal death after a focal ischemic stroke remains enigmatic. Although astrocytes form glial barriers that may protect surrounding tissue, how barriers develop and contribute to neuronal death is unclear. Here, we show that H₂O₂ induces astrocytic type I collagen (COL1)-production via miR-29-mediated post-transcriptional and fucosylation-d...

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Literature Corpus work
e275ab0b-bb8f-5afc-b7aa-408acc77e106
DOI
10.1101/2025.05.01.651594
Open publication

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H <sub>2</sub> O <sub>2</sub> -induced astrocytic collagen triggers neuronal death via fucosylation-dependent glial barrier formation upon ischemic strokeDOI 10.1101/2025.05.01.651594
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