Article

Spatiotemporal transcriptome analysis reveals that conversion of IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhage

2024-01-16

Abstract excerpt

<title>Abstract</title> <p>Intracerebral hemorrhage (ICH) is a type of stroke with high morbidity and mortality. Activation of microglia in response to ICH can lead to neuroinflammation, which can further exacerbate brain damage and neuronal death. By integration of single-cell RNA sequencing (scRNA-seq) and spatial transcriptome (ST) technologies in rat ICH model, we demonstrated that a microglia subtype (MIkzf1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5dfd56b6-7146-51c5-8324-43e4532dadb0
DOI: 10.21203/rs.3.rs-3765942/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal transcriptome analysis reveals that conversion of IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhageDOI 10.21203/rs.3.rs-3765942/v1Read

A spatiotemporal immune atlas of subarachnoid hemorrhage from single-cell and spatial transcriptomicsSemantic proximity Read

Single-cell RNA sequencing reveals the evolution of the immune landscape during perihematomal edema progression after intracerebral hemorrhageSemantic proximity Read

Single-Cell Analysis of Microglia and Monocyte Dynamics Uncover Distinct TNF-α-driven Neuroimmune Signatures after Intracerebral HemorrhageSemantic proximity Read

Single-cell RNA analysis reveals the cell atlas of human intracranial aneurysm and rupture-related inflammation featuresSemantic proximity Read

Identification of immune-related biomarkers for intracerebral hemorrhage diagnosis based on RNA sequencing and machine learningSemantic proximity Read

Mononuclear myeloid cells mount an adaptive protective response to intracerebral haemorrhage by activation of NRF2Semantic proximity Read

Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematomaSemantic proximity Read

Intracerebral Hemorrhage Induces Inflammatory Gene Expression in Peripheral Blood: Global Transcriptional Profiling in Intracerebral Hemorrhage PatientsSemantic proximity Read

Unique Subtype of Microglia in Degenerative Thalamus After Cortical StrokeSemantic proximity Read

Single-Cell Transcriptomics Analysis Reveals the Promotion of Mitochondrial Hyperactive Microglial Subpopulations by CSF1R following StrokeSemantic proximity Read

Therapeutic Role of Microglia/Macrophage Polarization in Intracerebral HemorrhageSemantic proximity Read

Irf8 exacerbates hypertensive intracerebral hemorrhage by mediating a pro-inflammatory phenotype of microglia through the Stat1/Trim5 axis.Semantic proximity Read