Article

Fibrin-containing Hydrogels Regulate Human Astrocyte State and Neuronal Reprogramming

2025-11-06

Abstract excerpt

Astrocytes are key components in reactive gliosis after brain injury, yet defined in vitro models dissecting the influence of extracellular matrix (ECM) components enriched after injury, such as fibrin, on human astrocyte behaviour and function are still missing. Here, we use fibrinogen-derived fibrin and fibrin-alginate-RGD (FAR) 3D hydrogel substrates to examine the influence on human iPSC-derived astrocyte beh...

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Literature Corpus work: d7f81a75-482a-5869-87f9-5c90af40a76a
DOI: 10.1101/2025.11.05.686711

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