Article

Glycan-coated nanoparticles mimicking the ischemic glycocalyx scavenge the complement system conferring protection after experimental ischemic stroke

2026-04-01

Abstract excerpt

Glycoproteins lining the luminal endothelial surface form the glycocalyx, composing the tripartite blood brain barrier. We explored the glycocalyx as a source of danger signals for complement lectin pathway after ischemic stroke. Our data indicate that hypoxic microvascular cells increased α-D-mannosyl and N-acetylglucosaminyl exposure after re-oxygenation, favoring mannose binding lectin (MBL) pathogenic depositi...

Identifiers and source

Literature Corpus work: 1209a6c8-5efc-59cd-abf8-678f91155c8c
DOI: 10.64898/2026.03.30.715069

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glycan-coated nanoparticles mimicking the ischemic glycocalyx scavenge the complement system conferring protection after experimental ischemic strokeDOI 10.64898/2026.03.30.715069Read

Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and ComplementSemantic proximity Read

The neurovascular extracellular matrix in health and diseaseSemantic proximity Read

H <sub>2</sub> O <sub>2</sub> -induced astrocytic collagen triggers neuronal death via fucosylation-dependent glial barrier formation upon ischemic strokeSemantic proximity Read

Sweet Aging: Glycocalyx and Galectins in CNS Aging and Neurodegenerative DisordersSemantic proximity Read

An insight into new glycotherapeutic in glial inflammation: Understanding the role of glycosylation from acute to chronic phase of inflammationSemantic proximity Read

The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood–Tissue BorderSemantic proximity Read

Mannan-binding lectin--a soluble pattern recognition molecule.Semantic proximity Read

Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?Semantic proximity Read

Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease?Semantic proximity Read

Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage.Semantic proximity Read

Association of Lectin Pathway Protein Levels and Genetic Variants Early after Injury with Outcomes after Severe Traumatic Brain Injury: A Prospective Cohort Study.Semantic proximity Read

Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke.Semantic proximity Read