Genome Editing Is Induced in a Binary Manner in Single Human Cells

Abstract excerpt

Even when precise nucleotide manipulations are intended, the outcomes of genome editing can be diverse, often including random insertions and deletions. The combinations and frequencies of these different outcomes in single cells are critical not only in the generation of genetically modified cell lines but also in the evaluation of the clinical effects of genome editing therapies. However, current methods only an...

Topics

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• CRISPR-Associated Protein 9
• Deoxyribonuclease I
• DNA End-Joining Repair
• Electroporation
• Gene Editing
• Protein Phosphatase 2
• RNA, Guide, CRISPR-Cas Systems
• Spinocerebellar Ataxias

Identifiers and source

Literature Corpus work

e26f540c-8caa-5b2d-8b25-39a9458eaf7c

DOI

10.1101/2022.03.04.482947