Article

Trisomy 21 Impairs Synchronized Activity in Human Down Syndrome Cortical Excitatory Neuron Networks

2024-12-28

Abstract excerpt

Down syndrome (DS) is the most common genetic cause of intellectual disability, affecting one in 700 live births worldwide, and is caused by trisomy of the human chromosome 21 (Hsa21), yet the cellular and molecular mechanisms driving neuronal network dysfunction remain poorly understood. Here, we investigated whether trisomy 21 (TS21) alters the spontaneous synchronised activity of excitatory neuron networks, pot...

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Literature Corpus work: e24cdcf6-b8ef-5d8a-8207-f651852efb06
DOI: 10.1101/2024.12.27.630530

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